Hedgehog signalling: Ci complex cuts and clasps
نویسنده
چکیده
Hedgehog (Hh) signalling in Drosophila inhibits partial proteolysis of the transcription factor Cubitus interruptus (Ci), and the ability of a complex containing Ci and the kinesin-related protein Costal-2 to bind microtubules. These changes are proposed to turn Ci from a repressor to an activator of Hh-target genes.
منابع مشابه
Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway
The Hedgehog (Hh) family of signalling proteins [1] mediate inductive interactions either directly or by controlling the transcription of other secreted proteins through the action of Gli transcription factors, such as Cubitus interruptus (Ci) [2]. In Drosophila, the transcription of Hh targets requires the activation of the protein kinase Fused (Fu) and the inactivation of both Suppressor of f...
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عنوان ژورنال:
- Current Biology
دوره 7 شماره
صفحات -
تاریخ انتشار 1997